Just a newbie question: Would it be beneficial that body itself generates transcriptional repressor proteins (via mRNA vaccine) that bind to specific cancerous mutation genes instead of giving some medicine that has similar inhibitory goals?
(Sorry, I'm just trying to learn cell biology on my own.)
it is difficult enough to target a cell and deliver to the cytoplasm, when you attempt to move further and deliver to the nucleus this is further difficulty.
if you are certain you have a specificly targeted delivery that stays away from non cancerous cells you can use mRNA to create labels [antigens] on the cell surface that the immune system interprets as pathogenic, thus immuno targeting oncocytes for destruction.
(Sorry, I'm just trying to learn cell biology on my own.)