Imagine how boring the universe would be if we understood everything. I'm sure we'd adapt but it would be tough for a while knowing we accumulated the totality of knowledge.
There was a good Futurama episode about that. The Professor got ahold of a new microscope that let him see down to the smallest particle, and from that he discovered the unified theory.
He won the Nobel prize, but was tremendously unhappy. For, with no more questions to answer, what was the purpose of living?
Fry then asked a question in his savant way: why is the unified theory what it is, instead of something else?
The professor then realized there was another question to ask, one that would take decades to answer, thousands of postgrads, and flaming dump trucks of grant money. He was happy again.
“And, now that I've found all the answers, I realise that what I was living for were the questions!”
