Measured in grams like the 10^-38, there would still be lots of zeros first, so not 38 significant figures.
Besides, relative measurements are often easier than absolute ones, so even if you could determine that the masses of two objects of ~1g differed by 10^-38g, that wouldn't necessarily tell you the absolute masses to anywhere near that accuracy.
(m1-m2)/(D0mass) = 3x10^-15
10^-38 is an absolute measurement, not the ratio.