As far as I understand, and I don't understand much. Also I am not endorsing vanden Bossche because I don't understand much. Furthermore, just as everyone else, he is just trying to sell his vaccine over others'.
The issue is selective pressure. Yes, the virus will mutate. But under an mRNA vaccine, only the spike protein needs to mutate for the vaccine to be render useless. In other words: mutating the spike protein will give the virus access to very broad unimmunized population.
Up to that it makes perfect sense to me and my limited evolutionary knowledge. I can't tell wether is right or wrong. But it makes sense.
He goes further saying that antibodies from vaccines are more affine to the virus, even with mutated spike protein, this compromises the natural immune system, given it will try to fight off infection with useless vaccine-learnt antibodies rather than with natural antibodies. This will make the virus more deadly.
This seems off to me. I can't see the logic, but I will be happy to be corrected. How can something be ignored by the virus and be more affine to it?
Again, he says that all these issues are solved with his vaccine, once he finishes it.
> The issue is selective pressure. Yes, the virus will mutate. But under an mRNA vaccine, only the spike protein needs to mutate for the vaccine to be render useless. In other words: mutating the spike protein will give the virus access to very broad unimmunized population.
> Up to that it makes perfect sense to me and my limited evolutionary knowledge. I can't tell wether is right or wrong. But it makes sense.
The issue with this is that the spike protein has to mutate enough for vaccine induced immunity to fail to recognize it, but the spike protein is critical for the virus actually entering and infecting cells, and therefore there isn't a whole lot of mutating it can do while remaining functional.
On the other hand, there is some evidence that vaccines targeting more than just the spike protein (as well as natural immunity) may potentially be more at risk for the "antigenic sin" trap, in which the immune system fails to respond to mutated versions of a virus as well as it does to the original version it encountered.
The issue is selective pressure. Yes, the virus will mutate. But under an mRNA vaccine, only the spike protein needs to mutate for the vaccine to be render useless. In other words: mutating the spike protein will give the virus access to very broad unimmunized population.
Up to that it makes perfect sense to me and my limited evolutionary knowledge. I can't tell wether is right or wrong. But it makes sense.
He goes further saying that antibodies from vaccines are more affine to the virus, even with mutated spike protein, this compromises the natural immune system, given it will try to fight off infection with useless vaccine-learnt antibodies rather than with natural antibodies. This will make the virus more deadly.
This seems off to me. I can't see the logic, but I will be happy to be corrected. How can something be ignored by the virus and be more affine to it?
Again, he says that all these issues are solved with his vaccine, once he finishes it.