Reproduction is likely to always be an issue with psychedelics research, since people's responses are so variable. Any research would need to have unethically large numbers of subjects. Perhaps legalisation would change that, but the legalisation will always be dicey without reliable research. An ouroboros of an issue.
Do you wanna expand on this one? I can probably make some assumptions about what you meant, but they're all have obvious solutions so I'm left without a reasonable interpretation.
