A long, long time ago, I "broke" my dad's MS Works word processor. The D key just stopped working. Turns out that, during my fiddling around, I had created a macro that did nothing and had 'D' as a hotkey. It was the first time ever that I had "broken the computer".
That's something I discovered the other day on my pc.
At some point during the last year or so, I accidentally assigned a macro to the C key that did nothing but press the C key, so it was pretty much impossible to notice during normal use, except that holding it down behaved out of the ordinary.