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It's almost guaranteed to not be caused by Yersinia exclusively. Many whole-microbiome sequencing studies have been done, and this would have come up if it were that simple. More likely, a mix of Yersinia and other species will be selected for.

It does raise novel ideas for how to work with and interpret microbiome studies. I'd like to see microbiota in fecal samples be sequenced before and after a cold test, for example. But even then, you might not see any results. It could be a metabolomic problem more than a microbiome problem, or even more likely still, both combined with an immune repertoire problem and other dysregulations.




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