Probably not. Some hacks would not work anymore (eg. wallhacks). Yet, how would you detect, say, an aimbot identifying the pixels on the screen and simulating mouse moves?
How would you detect that, anyway? Behavioural analysis and neural networks?
It's not that hard to point a smartphone at a screen and have it send fake keyboard and mouse commands through USB, the challenge is in interpreting the pixels themselves. This is the analogue loophole all over again, for a different kind of DRM.
