Annonacin is found in the seeds but the fhe fruit is fine, IIRC. Also IIRC, regular consumption of paw paw with lime is linked to excellent improvements in liver function for extremely late-stage Hepatitis patients. Consider also Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037677/