Firefox + uBlock Origin. Or any other browser with built-in ad blocking like Brave or Vivaldi, probably the best solution for non-techie friends or relatives.
I has used Chrome and AdGuard on Android that works as a VPN service and MITM TLS. It works but sometimes false positives happens and removing them is a bit annoying. Now I use Samsung browser and Content Blocker, because I found that Samsung browser is better UI than Chrome, and it supports content blocker as a bonus..
Just an FYI, NoScript is made largely redundant with uBlock Origin since if you enable the "I am an advanced user" checkbox in it's settings, it will allow you to selectively block or allow third party scripts and frames.
I just switched from Chrome to Brave. The HN hivemind tends to jump all over Brave with criticisms of their "attention token" monetization scheme, but this criticism has never made any sense to me. I just....don't use BAT, and never think about it at all.
I use DNS66 and have done for a few years. Works really well with Chrome on Android. If you frequently use a VPN it means you need to remember to switch it back on.
Fwiw I'm on Android and use Chrome but curious for what people do