My experience with ClojureScript is you absolutely have to know the host environment because you will encounter type errors and the maintainers have negative interest in making them clear to users (as in flatly refused offers to contribute changes to make those errors easier to understand).
There is nothing worse than library or language maintainers who do not understand that "pure" error messages are absolute hell. If 99.99 % of the time a user should simply write x instead of y, the message should absolutely state that if possible.
