Vaccine mandates would probably be the most effective strategy. This would reduce the death toll and also otherwise severe disease (and also long covid from the data we are seeing) by a factor of 10. At that point, we might as well drop all other measures and live with 10k dead people from this per year. Currently, it's still at an unacceptable level for society, even if one is only considering the economic impact and doesn't care about human suffering.