It clearly can be handled, the question is what's the procedure to handle it correctly and do you trust your procedure? Manufacturer or someone regularly working with this kind of thing does know and trust, if you suddenly realize it wasn't quite what you signed up for backing off is clearly the better choice than trusting your guess at procedure. But risk can be managed a lot.

Although certainly over-confidence can also happen on the other end, e.g. if something that's quite similar to other dangerous things you work with suddenly has an additional trap. And Safety Datasheets are notorious for not necessarily representing actual in-use risks well.