There is currently a "Faster CPython"[1] project going on that seek to improve the speed of Python. With Python 3.11 later this year there will be several speed improvements targeting common uses of Python, which might make some of these existing speedup tricks irrelevant. Or at least less relevant.

[1] https://docs.python.org/3.11/whatsnew/3.11.html#faster-cpyth...