I refuse to do actual browsing without NoScript in place. No ads, no popups, nothing.
Well, sometimes there's literally nothing, because SPA, but most of time it's just some kind of cover or body opacity set to 0. Totally worth the tradeoff on desktop and mobile. No ads, man. No fucking ads
I use NoScript and have for years but it sure gets exhausting to go to a site and find, in many cases, several dozen scripts that have to be "temp trusted" to get anywhere. I usually give up.