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I think the Dutch knew about this back in the late 18th Century - https://en.wikipedia.org/wiki/Tobacco_smoke_enema

It's where the phrase "blow smoke up your arse" comes from.



This isn't related though. The fact that drugs can be absorbed through intestinal mucosa is well known, that's how suppositories work. And it was known in pre-colombian south america too. But here we are talking about oxygen.


That wiki page is quite something...




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