As another hold-out on Jinja, what pushed you over the edge? Half of the appeal to me in Django is that if you follow the easy path, one project should look like another. Breaking conventions for a few template niceties has not seemed worth it (although, I am not a front end guy, and survive on very barebones presentation).
Using Tailwind without a frontend js framework. I needed a way to create lightweight “components” ala React but on the backend, because otherwise you’re either copy pasting classes like mad or (ab)using tailwind’s @apply.
I've been gradually removing all use of Jinja macros from our projects as they make debugging so much more painful. Everything now goes in template globals, which lets you debug them the same as anything else, gives far clearer stack traces and lets you do clever things with caching.