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I had a similar revelation for structural biology, applying the physics I learned for bridges and buildings to microscopic proteins. They are structurally like a cathedral built by a blind and deranged architect. The fact that mechanically bend, pivot, and move like a complex machine at a micro scale to do real work is the most sci-fi thing I can conceive of.

Think of a even a simple walking protein like Kinesin [1]. What is not shown in the video is that this is all happening in a hurricane of molecules battering it from all sides. Each part of the structure is being pushed, pulled, bent, robot made out of sticks and rubber bands.

https://www.youtube.com/watch?v=y-uuk4Pr2i8



> They are structurally like a cathedral built by a blind and deranged architect

That's one of the best things I read all week.


The other word missing is "cheap". Proteins are under a massive selection pressure: many thermodynamic reactions in fundamental bits of biology are as thermodynamically efficient as they can be, else some slightly more efficient mutant would have out-competed it aeons ago.

I became interested in biology as a physicist when I realised that all of the problems, on some level, boil down to putting a load of lego pieces in a box, shaking it up with some energy not terribly different to k_B T, and getting a fully-formed, self-replicating lego models out the other end. It's all physics. It's all utterly incomprehensibly mind-bogglingly complex with layers of complexity wrapped around each other, and far out of the realms of either physics or chemistry to compute completely. It's why I work at the intersection of the two fields.

Another famous paper, often-mentioned, related to this is "How a biologist would fix a transistor radio", essentially armed only with a shotgun. The tools of modern molecular biology may be scalpels rather than shotguns, but still, the idea is arguably the same.


> It's why I work at the intersection of the two fields.

Sounds fascinating. May I ask which field that is/what type of work you do?


Associate professor of medical physics & molecular imaging

In their profile


I was about two sentences into the parent comment when these videos came to mind. If I had seen just about anything done by Drew Berry when I was in middle school I probably would be in a completely different career:

https://www.youtube.com/results?search_query=Drew+Berry+anim...




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