Strange thing, I tried it on my FireTV to block youtube ads, but it didn't work. I wouldn't be surprised if the FireTV monkies around with user settings. The other explanation could be that youtube uses the same hostname for videos and ads, so the DNS blocking can't distinguish.
I used a pi-hole, but wanted it to work outside my home as well. NextDNS uses many of the same blocklists, and I happily pay $20/year for it. Also has apps for devices that roam from the house.
They try to make it super easy: https://pi-hole.net/ and I have no recollection of encountering any issues.
OTOH I am a software engineer working with Linux and network related stuff.
The issues comes later when some pages may break. When that happens you need to stop bashing your computer and add some URLs to the Pi-hole whitelist (or skip those parts of the web...). In my experience there has been few issues. Some enterprisey stuff my wife needed for work depended on some oracle tracking URLs that were blocked if I remember correctly.