More to your question: what happens is your tolerance for meaninglessness decreases, which has good and bad side effects.

I think part of what keeps me locked on to the hedonistic treadmill is that a lot of other people (including my partner) don't like who I am when I'm trying to stay off it. I tend to get more intense about a lot of things most folks don't care about.

It's funny, out of my whole family & friend circle I'm probably doing the most damage to myself via self medication, but when I try to get serious about things that matter and take a break from intoxicants, I end up doing just as much damage or more by putting my relationships through pointless trials of fire.

But I know what you mean about meaning. When it's good, it's really good and worth every bit of seeking.

It's unfortunate there are so many pitfalls to dodge for so many of us.

Others in your life may say they support your emphasis on spiritual growth, but what if that entails being passed up for a promotion, and, ergo, a raise? Most families would appreciate an extra $1k a month. Not every situation is either-or, but you quickly get a sense for what pragmatism means to people.

Often, it means comfort.

I hope you find the courage to continue to pursue meaning. It is good, as you say. Me, I made a bit of a deal with myself to make it a very high priority in my life when it is lacking. When necessary, meaning goes into the non-negotiable bucket.