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> I feel the performance must be more than 100x slower than before!

Not too far off. This paper [0] compared 27 languages for speed and energy efficiency (which is very interesting).

Python was 72 times slower than C and consumed 76 times more energy.

I think Python is a very useful language at many levels. Great for prototyping stuff. No doubt about that. If performance and energy efficiency are important, it seems obvious one has to look elsewhere.

[0] https://haslab.github.io/SAFER/scp21.pdf



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