I started on DOS and early Linux. F-keys absolutely make sense. I never incorporated home, end, page up/down into my flows. Essentially anything to the right of the arrow keys has no use in my life except SysRq and delete. The keyboards I liked best had the large backwards east asian mcnugget style enter key. These days I use an ergodox. Ortholinear is meh, but everything else about it is great.