> For obvious reasons, genetic material is very hard to get into a cell. The immune/digestive system fights it!
That's quite true, but it's true precisely because it's horrifically disruptive. (And the immune system has had more time to evolve protections against that disruption than it has for previously unheard of synthetic polymers.)
(Although to be clear, the new and exciting failure modes probably wouldn't involve the synthetic DNA actually getting inside of cells. (Sheer quantity might be sufficient to shove it's way through a phospholipid bilayer, but probably not.))
That's quite true, but it's true precisely because it's horrifically disruptive. (And the immune system has had more time to evolve protections against that disruption than it has for previously unheard of synthetic polymers.)
(Although to be clear, the new and exciting failure modes probably wouldn't involve the synthetic DNA actually getting inside of cells. (Sheer quantity might be sufficient to shove it's way through a phospholipid bilayer, but probably not.))