Also anecdotal, but everyone metabolizes these classes of drugs differently. I'm an "ultra-rapid metabolizer" of a slew of SSRIs, so they're next to worthless for me compared to other medications.

Also anecdotal. And some people are ultra-slow metabolizers, which can cause the drugs to stay in the body longer than anyone could have anticipated. So the effects of 1 pill daily can feel like twice that amount since previous day dosis is still in the blood.

SSRIs affect me strangely. I feel mentally like I’m not depressed but then I have all of the symptoms of depression amplified. Oversleep, no motivation etc but hey I feel like I’m not sad internally.