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I am their happy customer. I have successfully grown fluorescent yeast, and reproduced the CRISPR bacterial genetic modification protocol. Their support is awesome.

It is also possible to e.g. buy an old qPCR machine and corresponding perishables (I was slightly scared when a DHL truck delivered me a cold box full of dry ice), and run even more interesting experiments at home.

And, you can open an account at Sigma-Aldrich and order chemicals there as a hobbyist researcher (I did, and it worked).



Same here. Been a happy customer of theirs for years & even attended one of their Biohack the Planet conferences back before Covid. Everyone that I met who worked there was great. The team really goes above & beyond to make their customers happy and to promote citizen science.


Where are you at? I am a hobby chemist and getting a sigma aldrich account is rly hard in europe as a private person


Switzerland.

I had to sign all the papers promising them I won’t be using their chemicals for anything stupid, but otherwise they were friendly enough.


Now they're going be like "why is there suddenly a 10x increase in requests for individual accounts?" Haha


Well, their products are really expensive (like, outrageously expensive for a hobbyist). From them, I only bought geneticin and something else relatively unsophisticated; if I can source the compounds I need literally from anywhere else, I'd be better doing that.


I'm curious about the yeast part. I heard it's difficult/expensive to grow yeast at home, as opposed to bacteria. Are there online tutorials that you used? I've seen plenty of bacterial modification tutorials, but not so much for yeast.




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