you should at least take a brake where you use your legs every hour or more often because if not it will noticeable increase the chance of blot clots in your veins and in turn stuff like heart attacks (long term wrong behavior leading to increased risk over the long term, no relevant per-case risk)
similar you should change the focus distance of you eyes often enough as it does reduce eye strain (similar light conditioning in your room) and the easiest way to do it is to look not at your screen e.g. when standing up and moving around (and if well done maybe the glasses from Apple can simulated depth in a way which does lead to changes in eye focus)
Having a walking band below your desk and looking around your room outside of the window or similar will also fix this issues quite efficiently, at the cost of being less lazy (and issues for people with certain kind of back issues).
you should at least take a brake where you use your legs every hour or more often because if not it will noticeable increase the chance of blot clots in your veins and in turn stuff like heart attacks (long term wrong behavior leading to increased risk over the long term, no relevant per-case risk)
similar you should change the focus distance of you eyes often enough as it does reduce eye strain (similar light conditioning in your room) and the easiest way to do it is to look not at your screen e.g. when standing up and moving around (and if well done maybe the glasses from Apple can simulated depth in a way which does lead to changes in eye focus)
Having a walking band below your desk and looking around your room outside of the window or similar will also fix this issues quite efficiently, at the cost of being less lazy (and issues for people with certain kind of back issues).