Unfortunately, all it takes is something like Genshin Impact's anti-cheat system - which runs at the kernel / ring 0 level [1] - to be compromised, and then it's game over anyways.

Not to mention the potential of "what if the anti-cheat is deliberately programmed to be malicious?". A dismal state all around.

[1] https://genshin.hoyoverse.com/en/news/detail/103720