The problem with that is you need (one of many) server-side options to respond to the events... you could do a TodoMVC HTMX front end, but what would you use for the backend to work with it? Go, C#, Rust and a handful of others seem like pretty natural options, but as with all things, YMMV.

I mention C# in that ASP.Net MVC + Razor seems like a very clean match to the HTMX paradigm.