The DE itself, yes. This is true of GNOME as well once the hidden setting is enabled. Unfortunately there's still individual programs which don't behave correctly, which for now means that 1x or 2x displays are still best if a trouble-free, low-tinkering experience is the goal.
I use 150% on my main monitor and everything looks perfect except for two proprietary apps installed through flatpak: Zoom and Spotify. These two are not really known to be quality software in the first place so I think it is safe to blame them for this quirk.
