> Although recognized as an experimental carcinogen when used in high laboratory doses, there is inadequate evidence to classify Agaritine as carcinogenic to humans in amounts ingested from consuming mushrooms
I mean, if you wanted to be ultra-cautious you might avoid it, but it’s IARC Group 3. Unless you have a _very_ carefully controlled diet, it’s should probably not be high on your list of concerns, carcinogen-wise.
I don't know about saccharin, but tea is known to block iron absorption substantially, and coffee reduces cerebral blood flow (CBF) by virtue of its high caffeine content. Those are just two negative, non-trivial effects coming from those beverages.
Being in the same "group" doesn't mean it's healthy to eat long term. There need to be randomized double blind controlled trials and warning labels on synthetic foods.
Things get put in this group when the trials (generally on animals; you’re not going to get go ahead for trials of possible carcinogens on humans, generally) show inadequate evidence of carcinogenicity. Next group up is where there’s some, but ambiguous evidence on animals. For reference, agaratine is in group 3; red meat is in 2A, _two_ groups up, and most people are okay with eating that.
> warning labels on synthetic foods.
We’re talking about mushrooms here; mushrooms aren’t synthetic.