I don't like how this issue is constantly dismissed out of hand. It very obviously is actually a massive glaring issue which severely limits what clojure can reasonably be used for. Nobody would ever accept a 1 second startup time for CLI applications that we use all the time like git, kubectl, npm, docker, etc.
40ms? Clojure Hello World startup time is like 600ms and up. Yes sometimes you run npm and kubectl for hours but most of my usage is just running individual commands that take less than a second.