The audacity you have to claim causality here is wild. I’m a geneticist and boy let me tell you that it is not easy to unravel causality. Even in the systems I’ve studied for years, I would never make claims like this.
If you are a geneticist, you would know genetic correlates. The only causality of AD that I assert is with lifestyle factors and genetic factors, e.g. APOE4, that govern neuroinflammation, as is strongly established.
APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease (PMID: 38710950)
> The study concludes that APOE4 homozygotes represent a genetic form of AD
Healthy lifestyle and the risk of Alzheimer dementia (PMC7455318)
> Compared to participants with 0 to 1 healthy lifestyle factor, the risk of Alzheimer dementia was 37% lower (pooled HR 0.63, 95% CI 0.47–0.84) in those with 2 to 3 healthy lifestyle factors and 60% lower (pooled HR 0.40, 95% CI 0.28–0.56) in those with 4 to 5 healthy lifestyle factors.
With regard to lifestyle factors, here is some evidence to get you started:
Healthy lifestyle and the risk of Alzheimer dementia (PMC7455318)
> Compared to participants with 0 to 1 healthy lifestyle factor, the risk of Alzheimer dementia was 37% lower (pooled HR 0.63, 95% CI 0.47–0.84) in those with 2 to 3 healthy lifestyle factors and 60% lower (pooled HR 0.40, 95% CI 0.28–0.56) in those with 4 to 5 healthy lifestyle factors.
I tried reading your post with an open mind, but starting with your first citation of PMID 38753870 you neglect to mention it was a study done in genetically modified mice. For you to claim it is "the single most powerful supplement for lowering its risk might be urolithin-A" right after you confidently assert "Beta-amyloid is a symptom of AD, not the cause" looks like you're just as bad at jumping to conclusions as the beta-amyloiders you "don't know how could mix this up."
In effect I asserted that neuroinflammation is at the root of AD, and that factors that lower it will in turn lower the risk of AD. This I stand by completely, and so the lifestyle factors that lower neuroinflammation are relevant. As for PMID 38753870, it is just one of many relevant studies showing brain health benefits from urolithin A. In particular, urolithin A works by inducing mitophagy (among its many other effects), with mitophagy improving mitochondrial health and therefore metabolic health. Unhealthy lifestyle choices compromise the excitatory/inhibitory balance in the brain, and it goes downhill from there.
What we have today in the field of drug development, and we have had this for many years now, is the development of cost-inefficient late-stage treatments that maximize revenue exploitation, but often don't even work. Instead, what we need is early-stage and preventative diagnostic measures, and cheap scalable generic small molecules or vaccines, coupled with lifestyle and environmental changes, that together reverse or treat the condition when it's still reversible or treatable. We will not get this from the FDA because it's 100% in bed with the scientific mercenaries that like to call themselves scientists. Moreover, I assert that most of the ones downvoting my comments here represent the mercenaries that work in the industry to earn some of this exploitative revenue for themselves, and they don't want the size of the pie to be reduced.
Things to consider:
* Alzheimer might not be a disease, but a syndrome. (several diseases that look about the same)
* Alzheimer's onset might be multifactorial (like diabetes, unlike Hungtington's)
* Everything we know about the pathophysiology of Alzheimer might be wrong. What we believe is right would actually prevent us from making progress. It doesn't help that very loud idiots crave for recognition rather than discovery.
It's not known but among other things there is some evidence that it comes from a viral infection earlier in life. Multiple sclerosis is another thing like that.
> Be kind. Don't be snarky. Converse curiously; don't cross-examine. Edit out swipes.
> When disagreeing, please reply to the argument instead of calling names. "That is idiotic; 1 + 1 is 2, not 3" can be shortened to "1 + 1 is 2, not 3."
Your comments in this thread would be more constructive without the swipes.
It's all well and good for you to discipline me, and I will be happy to edit and abide, but what's not good is you letting others unfairly chew me alive. It's just wrong.
Yes, you're right. Multiple people in the thread needed to be reminded of this.
I wrote my comment in reply to you since you seemed to be the most active, and several of your replies were the most recent at the time I was responding.
