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I'm one of those.

I have this super weird thing where I'm hyper-sensitive to caffeine, and its effects will hit me sometimes 6+ hours later.

If I have a cup of coffee in the late morning, it will keep me up most of the night, and a single cup of coffee will make me manic-ish.

People have (doctors included) told me that what I was experiencing was impossible, that caffeine in metabolized in a certain way and completely out of your system quickly.

Turns out, that's true with most people, unless you have a variant in the CYP1A2 gene, which can cause the effects I experience.




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