Can go back to Arthur Conan Doyle, who disliked having to keep writing Sherlock Holmes stories. (Famously killing him off, only to bring him back later when a successful story was needed.)
One can imagine poor, blind, Homer, having been fed up with his Odysseus fen asking for yet another year's worth of adventures, deciding to sing about Ithaca and Penelope once and for all.
Reminds me of J.D. Salinger and how he was always mildly irritated that despite having written many other novels (Franny and Zooey, Bananafish, etc.) he is only ever remembered for Catcher in the Rye.