If you've got the budget for it, e-ink monitors are becoming more available recently, and I've heard that they make a huge difference for eye strain. There are still only a few companies manufacturing panels that large, and I think the framerate can be pretty jarring for anything other than text, but I have been keeping an eye out for when the prices drop.
For most people, using e-ink for general-purpose computing tasks is going to be so jarring and unpleasant that it's extremely difficult to recommend to anyone who doesn't have severe eyestrain issues and has tried and failed more typical accommodations. I adore e-ink for reading, and own several e-ink readers in various form factors, but the tradeoffs just don't make sense for a desktop computer for most people unless staring at your monitor for eight hours a day is causing you physical harm.
