Ask Hawaii what happened when a bunch of businessmen wanted more profits and less government oversight! Back then it was Dole (the PERSON) and sugarcane companies, today it is auto manufacturers and probably access to the northern sea route that is rapidly becoming de-iced and relevant for shipping to bypass the Panama Canal. Canada better take this threat seriously and treat the USA, at the very least, like a neighbor who is shooting a rifle at a massive tank of propane.
Europe is already weak, economically and militarily. I don't know how long our votes will matter when we have a belligerent and powerful neighbour.