Use direnv for automatically creating, activating, and deactivating your virtual environments. I don't know how anyone lives any other way. Just put this in a .envrc file (substituting whichever python version you are using):

  layout python python3.12
  pip install --upgrade pip
  python -m pip install -r requirements.txt

Looks like direnv can be extended to use uv:

https://github.com/direnv/direnv/wiki/Python#uv