I am 8 months in, you do develop a tolerance over time to the drug (and why you need to increase the dosage progressively). I have gone up slower than the prescibed steps but still, this drug is to help doing diets, I don't think it would work as a long term medication. And as far as I can tell, when you get off the drug or have become tolerant to the current dosage, it is easy to gain back some weight if you are not careful. So the point being I don't think it will suppress completely obesity, but it will certainly help people make a time limited effort to go down to a lower weight.
Some doctor advised a protocol: stay on GLP-1 for 3 months, then take metformin for a month or two; then repeat the cycle. I have to dig out the source for this.
I’ve been on it for over 2 years now. Yes you plateau, and if you go off of it (as I had periodically), you will regain weight. Hoping my weight loss resumes now that I’m back to the maximum dosage for a few weeks. As it’s 5pm and I just ate for the first time today, I can confidently confirm that my appetite is well suppressed.
Interesting, what is the end game then if you need to be on the drug to keep the weight off but you also develop resistance to it over time?
I wonder how the body reacts after being on the drug for years at a time and then you cut it off, are the cravings stronger than before you started the drug?
Doesn't mean you go back all the way up. And I don't know if the resistance wears off if you stop taking it. What I am hoping is to end up in an end state where I can keep the weight within a 5-7kg range and go on the drug for 2-3 months once a year to go back to the bottom of the range.
I think the craving is primarily a function of how much your stomach expects food, ie the more food the more craving, but also you can get it used to a lower regime. And to external factors like stress, tiredness, cold, etc.
