YMMV, but in my experience, Python's top use cases tend to require fewer dependencies, not more. Many trivial tasks are already built into the language. Not saying Python is perfect, but it's definitely well-oriented in that regard. I'm curious in what kinds of use cases have you found the opposite to be true?

I think the classic Python vs. Perl question ultimately comes down to using what you feel most comfortable with. People are different, and that's totally fine.