You can, it even ships with two files you can use as examples in mc.{emacs,vim}.keymap. The vim one has my favorite comment in a config file:
[editor]
# No remapping, just use vim instead of mcedit
Given that you can specify the bindings config to use at startup with --keymap you can even configure task specific sets of bindings. This combined with extfs and custom menus makes it a great way to make a personal interface to non-file data sources too.
