Well, thanks. That's certainly better than what made it into wikipedia. But honestly: no? Only 41% of papers answering "yes" to an engaging and evocative hypothesis, in the era of the replication crisis, and especially after a decade and a half of the hypothesis sitting around in general lore, generally means "no, duh" in my experience.
As the site itself says, "evidence is still limited and more research is needed", which is definitely not "compelling". My money still sits on "nerd wish fulfillment". But we'll see.
Yeah, there are studies suggesting neurons, far more so than many peripheral cells, are especially vulnerable to insulin resistance. So by the time you see systemic insulin resistance by standard measures, the brain may already be slipping. I suppose this is why ketonic diet has any role in restoring cognitive function.
As the site itself says, "evidence is still limited and more research is needed", which is definitely not "compelling". My money still sits on "nerd wish fulfillment". But we'll see.