This depends entirely on how well the thing you're using bothered to support multiple platforms.
Browsers are pretty much the gold standard here, ironically. You might have to care if it's Firefox or Chrome but it's very rare for you to have to care if it's Firefox on Windows or Mac or Linux. It's exactly why React is simultaneously horrible and everywhere.
So it can be done, it's just a question of whether that framework has done it well, ideally while also doing other things well (unlike React).
Browsers are pretty much the gold standard here, ironically. You might have to care if it's Firefox or Chrome but it's very rare for you to have to care if it's Firefox on Windows or Mac or Linux. It's exactly why React is simultaneously horrible and everywhere.
So it can be done, it's just a question of whether that framework has done it well, ideally while also doing other things well (unlike React).