If you’re executing a script from an untrusted source, you should be examining it anyway. If it fails to execute because you haven’t installed the correct dependencies, that’s an inconvenience, not a lucky security benefit. You can write a reverse shell in Python with no dependencies and just a few lines of code.
it's a stretch to "executing a script with a build user" or "from a validated distro immutable package" to "allowing something to download evergreen code and install files everywhere on the system".
I've used Tiger/Saint/Satan/COPS in the distant past. But I think they're somewhat obsoleted by modern packaging and security like apparmor and selinux, not to mention docker and similar isolators.
most people like their distro to vet these things. uv et all had a reason when Python2 and 3 were a mess. i think that time is way behind us. pip is mostly to install libraries, and even that is mostly already done by the distros.