At the end of the day you need to find them and this is hard. A more practical strategy is to group the chromosomes in a way that gives you the desired ratio.
For example, if you have 4 male speakers
XY XY XY XY
Simply rearrange to form 2 females. The residual, YY is dead.
For example, if you have 4 male speakers
XY XY XY XY
Simply rearrange to form 2 females. The residual, YY is dead.
XX XX YY YY