It certainly can. I like to create a lot of small hobby sites for fun. I pay $20 for a VM with ~700MB of ram. How many JVM web apps can I fit on it vs node web apps?
Or, I run a few hundred servers at work, also on VMs. I want to create a process that needs to run on all of them in addition to what the server is actually used for. Maybe for monitoring, maybe for server management, etc. and I want it to have a REST API. Suddenly using 100MB matters to me.