That's one weakness of Objectivism which has become more apparent to me in the last few years. The philosophy seems to almost construct a platonic form of "rationality" and "self-interest" and never really reconnect with concretes, staying entirely in the abstract. So it ends up handling most cases pretty well, but a lot special cases get left behind.
Still, when I re-think through her reasoning again and again, I don't see how one could reach any different fundamental principles. Special cases are just that, and the best course seems to be to just deal with them as they arise.
Actually, her theory of "mind" is probably the worst flaw. All the modern psychological research indicates that the rule-following, conscious mind you use to do formal "reason" is a tiny, weak, singly threaded, monitoring rather than commanding subsystem in a brain that is mostly fast, parallel, unconscious, and NOT rational.
Still, when I re-think through her reasoning again and again, I don't see how one could reach any different fundamental principles. Special cases are just that, and the best course seems to be to just deal with them as they arise.