S3's not completely indestructible, but it is the most reliable platform I've encountered. During the ~1.5 years I was at Pinterest, we used S3 to store and serve all of the cached images on our site, with CDNs in front of course. We only ran into 2 incidents with S3, and only one of those would have affected "normal" customers. (The other was our own fault -- we suddenly started writing hundreds of files per second to a bucket that wasn't ready for this level of traffic.)