They run "on" Chrome, not in it. A separate icon, window, etc. You need to have Chrome installed, but it's different from ActiveX in that you're not going to see "plug-in missing" in the middle of a page somewhere.
Well, Activex was windows only. At least you can run in three big platforms now. And probably Android later. This is not activex, perhaps Adobe AIR is kind of similar, but it was not web centric.