AngularJS explicitly [1] states that its suited best for standard CRUD apps. If you need to do something which requires touching the DOM or some low level manipulation, better stay off it. We decided against it while building our GUI Editor ( adpushup.com), and decided on Backbone (w/ Backbone relational). Backbone is a library (as opposed to being a framework) and plays really nice with jQuery and vanilla JS.

However, there'll be projects/components for which AngularJS (or EmberJS) would be better suited, and we'll surely love to give it a try.

[1] : http://docs.angularjs.org/guide/overview