Central Iowa has a growing tech / startup sector that is home to many new tech companies. Cost of living is insanely low. I live in Ames, Iowa and work for a medium-sized tech company founded in 2008. Salaries here are comparable to what you'd find in Minneapolis or Kansas City, but with an even lower cost of living. If you're going to bootstrap a startup, Central Iowa is the place to be. Lots of talent and super low costs.
I just spoke at a conference in Des Moines, and there seems to be a real groundswell of support and enthusiasm for entrepreneurship in the state. Great to see. Lots of good people.